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GHRP-6

Category: Peptides · Last updated

GHRP-6 (Growth Hormone Releasing Peptide 6, His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂) is a synthetic hexapeptide developed by Cyril Bowers in the late 1980s as one of the first growth-hormone secretagogues. It is the historical precursor to Ipamorelin and Hexarelin.

Mechanism

  • Binds the Ghrelin_receptor (GHS-R1a)
  • Stimulates GH release from pituitary somatotrophs
  • Cross-reactivity: weakly raises cortisol and prolactin (less selective than Ipamorelin)
  • Stimulates appetite via central NPY/AgRP neurons

Relevance to research peptides

GHRP-6 is mentioned in this catalog as the older, less-selective historical reference compound. The current research focus is on the cleaner selective agonist Ipamorelin.

See also

Research framing only. Peppu Wiki documents the published research literature surrounding peptide compounds. Articles describe in-vitro and animal-model evidence, regulatory status, and community-reported protocols. Nothing on this site is medical advice, a recommendation for human use, or a substitute for consultation with a qualified clinician. All compounds discussed are research-use only. Citations should be verified at the source before relying on any quantitative claim.
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