Peppu Wiki← peppu.studio

TrkB receptor

Category: Receptors · Last updated

TrkB (Tropomyosin receptor kinase B, gene symbol NTRK2) is a single-pass transmembrane tyrosine kinase receptor. Its primary high-affinity ligand is BDNF (BDNF); it also binds NT-4/5 with high affinity and NT-3 with lower affinity.

Signaling

BDNF binding triggers TrkB dimerization and autophosphorylation, activating three downstream pathways:

  • Ras-MAPK → cell growth and differentiation
  • PI3K-Akt → survival and protein synthesis
  • PLCγ-PKC → calcium release and short-term plasticity

Relevance to research peptides

  • Semax · increased TrkB phosphorylation in rat hippocampus following intranasal administration (Dolotov et al. 2006; PMID 16996037)

See also

Research framing only. Peppu Wiki documents the published research literature surrounding peptide compounds. Articles describe in-vitro and animal-model evidence, regulatory status, and community-reported protocols. Nothing on this site is medical advice, a recommendation for human use, or a substitute for consultation with a qualified clinician. All compounds discussed are research-use only. Citations should be verified at the source before relying on any quantitative claim.
View edit history of this page