GIP receptor
Category: Receptors · Last updated
The GIP receptor (GIPR) is a class-B Gαs-coupled G-protein-coupled receptor whose endogenous ligand is GIP (Glucose-dependent Insulinotropic Polypeptide, 42 amino acids), an incretin secreted by intestinal K-cells in response to nutrient intake. GIPR is expressed on pancreatic β-cells, adipocytes, central and peripheral nervous-system neurons, and bone osteocytes.
Signaling
GIPR activation triggers adenylate cyclase → cAMP → PKA, producing glucose-dependent insulin secretion in β-cells. In adipocytes, GIPR signaling modulates lipid storage and turnover. Central GIPR has been implicated in appetite and food-reward circuitry.
Relevance to research peptides
- Tirzepatide · dual GLP-1R / GIPR agonist (Mounjaro / Zepbound)
- Retatrutide · triple GLP-1R / GIPR / GCGR agonist