Growth hormone receptor
Category: Receptors · Last updated
The growth hormone receptor (GHR) is a single-pass transmembrane class-I cytokine receptor expressed on hepatocytes and peripheral tissues. It is the primary downstream target of pituitary Growth_hormone and the main driver of hepatic IGF-1 production.
Signaling
GH binding induces GHR dimerization, activating the associated JAK2 tyrosine kinase. JAK2 phosphorylates the receptor cytoplasmic tail, creating docking sites for STAT5b, which dimerizes, translocates to the nucleus, and drives transcription of IGF-1, SOCS, and other GH-target genes.
Relevance to research peptides
The proposed mechanism of BPC-157 includes upregulation of GHR expression in injured tissue (Sikiric group preclinical literature). Tesamorelin and CJC-1295 act upstream at the GHRH_receptor, not directly at GHR.